Paula S. Henthorn
Professor of Medical Genetics with Tenure - Department of Clinical Studies
Chief, Section of Medical Genetics
Graduate Group Affiliations
Contact information
4030 Ryan/VHUP
3900 Delancey St
Philadelphia, PA 19104-6010
3900 Delancey St
Philadelphia, PA 19104-6010
Office: 215-898-8894
Fax: 215-573-2162
Fax: 215-573-2162
Email:
henthorn@vet.upenn.edu
henthorn@vet.upenn.edu
Publications
Education
B.S. (Biology/Genetics and Development)
University of Illinois at Champaign-Urbana, 1978.
Ph.D. (Genetics)
University of Wisconsin, 1984.
Permanent linkB.S. (Biology/Genetics and Development)
University of Illinois at Champaign-Urbana, 1978.
Ph.D. (Genetics)
University of Wisconsin, 1984.
Description of Research Expertise
Research InterestsCharacterization and therapy of canine and feline models of human genetic disease.
Key words: Dog, cat, molecular genetics, gene mapping, complex inheritance.
Description of Research
Research activities focus on the characterization of inherited diseases in dogs and cats, with goals of developing DNA-based tests that can be used to eliminate diseases from companion animals by selective breeding, and to develop and test therapeutic approaches for treatment of genetic diseases in both man and animals. In collaboration with other colleagues at the School of Veterinary Medicine, various heritable diseases are currently under study, including multiple forms of congenital heart disease, dilated cardiomyopathy, multiple forms of cystinuria, deafness, pontocerebellar hypoplasia, diabetes, and epilepsy.
Rotation Projects for 2007-2008
Please see Dr. Henthorn.
Lab personnel:
Michael Raducha, Lab Research Specialist
JunLong Liu, Lab Research Specialist
Selected Publications
Werner P, Raducha MG, Prociuk U, Sleeper MM, Van Winkle TJ, Henthorn PS.: A novel locus for dilated cardiomyopathy maps to canine chromosome 8. Genomics 91(6): 517-521, June 2008.Suter SE. Gouthro TA. O'Malley T. Hartnett BJ. McSweeney PA. Moore PF. Felsburg PJ. Haskins ME. Henthorn PS. : Marking of peripheral T-lymphocytes by retroviral transduction and transplantation of CD34+ cells in a canine X-linked severe combined immunodeficiency model. Veterinary Immunology & Immunopathology. 117(3-4): 183-96, Jun 15 2007.
Fyfe JC, Kurzhals RL, Hawkins MG, Wang P, Yuhki N, Giger U, Van Winkle TJ, Haskins ME, Patterson DF, Henthorn PS.: A complex rearrangement in GBE1 causes both perinatal hypoglycemic collapse and late-juvenile-onset neuromuscular degeneration in glycogen storage disease type IV of Norwegian forest cats. Molecular Genetics and Metabolism 90(4): 383-392, April 2007.
VernauW. Hartnett BJ. Kennedy DR. Moore PF. Henthorn PS. Weinberg KL. Felsburg PJ.: T cell repertoire development in XSCID dogs following nonconditioned allogeneic bone marrow transplantation. Biol. Blood and Marrrow Transplantation 13: 1005-15, 2007.
Swerdlow MP. Kennedy DR. Kennedy JS. Washabau RJ. Henthorn PS. Moore PF. Carding SR. Felsburg PJ. : Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells. Veterinary Immunology & Immunopathology. 114(3-4): 313-9, Dec 15 2006.
Suter SE. Gouthro TA. McSweeney PA. Nash RA. Haskins ME. Felsburg PJ. Henthorn PS. : Optimized transduction of canine paediatric CD34(+) cells using an MSCV-based bicistronic vector. Veterinary Research Communications 30(8): 881-901, Nov 2006.
Goldschmidt MH. Kennedy JS. Kennedy DR. Yuan H. Holt DE. Casal ML. Traas AM. Mauldin EA. Moore PF. Henthorn PS. Hartnett BJ. Weinberg KI. Schlegel R. Felsburg PJ. : Severe papillomavirus infection progressing to metastatic squamous cell carcinoma in bone marrow-transplanted X-linked SCID dogs. Journal of Virology 80(13): 6621-8, Jul 2006.
Casal ML. Munuve RM. Janis MA. Werner P. Henthorn PS. : Idiopathic epilepsy in Irish Wolfhounds.[see comment]. Journal of Veterinary Internal Medicine 20(1): 131-5, Jan-Feb 2006.
Suter SE. Gouthro TA. McSweeney PA. Nash RA. Haskins ME. Felsburg PJ. Henthorn PS. : Isolation and characterization of pediatric canine bone marrow CD34+ cells. Veterinary Immunology & Immunopathology 101(1-2): 31-47, Sep 2004.
Werner P. Raducha MG. Prociuk U. Ostrander EA. Spielman RS. Kirkness EF. Patterson DF. Henthorn PS. : The keeshond defect in cardiac conotruncal development is oligogenic. Human Genetics 116(5): 368-77, Apr 2005.