Ralph Guenter Meyer
Contact information
Rm. 147, Myrin Building - Office
Lab 104, Myrin Building - Lab
382 W. Street Road
Kennett Square, PA 19348
Lab 104, Myrin Building - Lab
382 W. Street Road
Kennett Square, PA 19348
Office: 610-925-6148
Fax: 610-925-8121
Fax: 610-925-8121
Email:
meyerg@vet.upenn.edu
meyerg@vet.upenn.edu
Education
Dipl.Biol. (Cell and Molecular Biology)
University of Kaiserslautern, Germany, 1994.
Ph.D. (Molecular Cell Biology)
University of Kaiserslautern and German Cancer Research Center - Heidelberg - Germany, 1998.
Permanent linkDipl.Biol. (Cell and Molecular Biology)
University of Kaiserslautern, Germany, 1994.
Ph.D. (Molecular Cell Biology)
University of Kaiserslautern and German Cancer Research Center - Heidelberg - Germany, 1998.
Description of Research Expertise
Poly(ADP-ribose) metabolism, PARP, PARGSpermatogenesis
DNA base excision repair (BER)
DNA damage, strand breaks and genomic stability
Cell signaling defects in carcinogenesis
Molecular biology of viral vectors (AAV, AdV, FIV, HIV, MoMuLV)
Gene targeting
Selected Publications
Meyer R.G., Meyer-Ficca M.L., Whatcott C.J., Jacobson E.L., Jacobson M.K.: Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Experimental Cell Research 313(13): 2920-36, Aug 2007.Gao H., Coyle DL., Meyer-Ficca ML., Meyer RG., Jacobson EL., Wang ZQ., Jacobson MK.: Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Experimental Cell Research 313(5): 984-96, Mar 10 2007.
Meyer-Ficca ML., Scherthan H., Burkle A., Meyer RG.: Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma 114(1): 67-74, May 2005.
Meyer-Ficca ML., Meyer RG., Jacobson EL., Jacobson MK.: Poly(ADP-ribose) polymerases: managing genome stability. [Review] [30 refs] International Journal of Biochemistry & Cell Biology 37(5): 920-6, May 2005.
Gao H, Coyle DL, Meyer-Ficca ML, Meyer RG, Jacobson EL, Wang Z-Q, Jacobson MK: Effect of poly (ADP-ribose) glycohydrolase gene disruption on cellular responses to genotoxic stress. Proc Amer Assoc Cancer Res 46: 1788, 2005.
Meyer-Ficca ML, Meyer RG, Jacobson EL, Jacobson MK: Overexpression of poly (ADP-ribose) glycohydrolase (PARG) isoforms. Proc Amer Assoc Cancer Res 46: 1789, 2005.
Meyer-Ficca ML., Meyer RG., Kaiser H., Brack AR., Kandolf R., Kupper JH.: Comparative analysis of inducible expression systems in transient transfection studies. Analytical Biochemistry 334(1): 9-19, Nov 1 2004.
Cortes U., Tong WM., Coyle DL., Meyer-Ficca ML., Meyer RG., Petrilli V., Herceg Z., Jacobson EL., Jacobson MK., Wang ZQ.: Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Molecular & Cellular Biology 24(16): 7163-78, Aug 2004.
Meyer RG., Meyer-Ficca ML., Kaiser H., Selinka HC., Kandolf R., Kupper JH.: Plasmid-based generation of recombinant coxsackievirus B3 particles carrying capsid gene replacement replicons. Virus Research 104(1): 17-26, Aug 2004.
Meyer-Ficca ML., Meyer RG., Coyle DL., Jacobson EL., Jacobson MK.: Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Experimental Cell Research 297(2): 521-32, Jul 15 2004.