Perelman School of Medicine at the University of Pennsylvania

Center for Neuromodulation in Depression and Stress (CNDS)






The Center for Neuromodulation in Depression and Stress (CNDS)

The Center for Neuromodulation in Depression and Stress (CNDS) was founded in 2013 to augment the stellar programs already existing at Penn. 

The Center Objectives are to:

  • Spur new research on the science and treatment of affective disorders. We define affective disorders broadly to include mood and anxiety disorders in incuding PTSD. 
  • Fully integrate state-of-the-art neuroimaging with cross sectional and longitudinal phenotypic characterization, including blood and CSF biobanking 
  • Understand similarities and differences in brain-behavior interactions across treatment modalities. We investigate antidepressant, cognitive behavioral therapy (CBT), transcranial magnetic stimulation (TMS), and other neuromodulatory approaches.
  • Use molecular neuroimaging to identify changes in stress-related neuroplasticity, neuroreceptors, inflammatory cytokines, reactive oxygen species, amyloid and tau proteins in stress and depression-related disorders  
  • Capitalize on and strengthen efforts of the outstanding neuroscience community at Penn, including links within and across the Penn departments with stress and depression populations  
  • Mentor junior faculty and trainees who are focusing their training on issues related to affective illness